Drug interactions
Hydroxychloroquine + Ranolazine
Severity: Moderate
Hydroxychloroquine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine produces a dose-related QT prolongation, and hydroxychloroquine may add to it. The combination may raise the risk of ventricular arrhythmia, especially in patients with heart disease.
What this interaction means in plain words
Hydroxychloroquine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG and monitor the QTc after starting the combination, and keep ranolazine at the lowest effective dose. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Ranolazine?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine produces a dose-related QT prolongation, and hydroxychloroquine may add to it. The combination may raise the risk of ventricular arrhythmia, especially in patients with heart disease.
How serious is the interaction between Hydroxychloroquine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor the QTc after starting the combination, and keep ranolazine at the lowest effective dose. Correct potassium and magnesium abnormalities.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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