Drug interactions
Hydroxyzine + Leuprolide
Severity: Moderate
Hydroxyzine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is associated with QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to this effect. The combined risk is greater in older patients, those with heart disease, or with electrolyte abnormalities.
What this interaction means in plain words
Hydroxyzine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation: hydroxyzine blocks cardiac hERG potassium channels while androgen deprivation lengthens repolarization.
What to do
Use the lowest effective hydroxyzine dose and consider an alternative antihistamine in patients with QT risk factors. Check ECG and electrolytes if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Leuprolide?
MediHelp rates the interaction as moderate. Hydroxyzine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is associated with QT prolongation and torsades de pointes, and androgen deprivation with leuprolide may add to this effect. The combined risk is greater in older patients, those with heart disease, or with electrolyte abnormalities.
How serious is the interaction between Hydroxyzine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose and consider an alternative antihistamine in patients with QT risk factors. Check ECG and electrolytes if the combination is needed.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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