Drug interactions
Hydroxyzine + Lisdexamfetamine
Severity: Minor
Hydroxyzine and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine, while lisdexamfetamine is a stimulant. Their opposing effects on alertness may blunt each other, and the net effect is unpredictable. Hydroxyzine can also prolong the QT interval, which may matter in patients with other cardiac risk factors.
What this interaction means in plain words
Hydroxyzine and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxyzine belongs to Respiratory; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal (H1 antagonism versus amphetamine-mediated catecholamine release).
What to do
No routine dose change is needed; monitor alertness and sleep, and check heart rate and rhythm if there are other QT-prolonging risks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Lisdexamfetamine?
MediHelp rates the interaction as minor. Hydroxyzine and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine is a sedating antihistamine, while lisdexamfetamine is a stimulant. Their opposing effects on alertness may blunt each other, and the net effect is unpredictable. Hydroxyzine can also prolong the QT interval, which may matter in patients with other cardiac risk factors.
How serious is the interaction between Hydroxyzine and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor alertness and sleep, and check heart rate and rhythm if there are other QT-prolonging risks.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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