Drug interactions
Hydroxyzine + Metoclopramide
Severity: Moderate
Hydroxyzine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is sedating and has anticholinergic properties, which may add to the CNS effects of metoclopramide. Anticholinergic activity may also oppose metoclopramide's prokinetic action. Both agents can contribute to QT prolongation risk in susceptible patients.
What this interaction means in plain words
Hydroxyzine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, anticholinergic antagonism of prokinetic effect, and possible additive QT effects.
What to do
Monitor for sedation and movement disorders. Consider an ECG and electrolytes in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Metoclopramide?
MediHelp rates the interaction as moderate. Hydroxyzine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is sedating and has anticholinergic properties, which may add to the CNS effects of metoclopramide. Anticholinergic activity may also oppose metoclopramide's prokinetic action. Both agents can contribute to QT prolongation risk in susceptible patients.
How serious is the interaction between Hydroxyzine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and movement disorders. Consider an ECG and electrolytes in patients with other QT risk factors.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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