Drug interactions
Hydroxyzine + Perampanel
Severity: Moderate
Hydroxyzine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause dizziness, somnolence and psychomotor impairment, and hydroxyzine adds sedation. Combined use may increase falls and impair driving ability.
What this interaction means in plain words
Hydroxyzine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients about sedation, falls and driving restrictions, and consider lower hydroxyzine doses. Monitor for mood or behavior changes associated with perampanel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Hydroxyzine with Perampanel?
MediHelp rates the interaction as moderate. Hydroxyzine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause dizziness, somnolence and psychomotor impairment, and hydroxyzine adds sedation. Combined use may increase falls and impair driving ability.
How serious is the interaction between Hydroxyzine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation, falls and driving restrictions, and consider lower hydroxyzine doses. Monitor for mood or behavior changes associated with perampanel.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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