Drug interactions
Hydroxyzine + Posaconazole
Severity: Major
Hydroxyzine and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so concurrent use may increase the risk of torsades de pointes. Risk is greater in patients with electrolyte imbalance, heart disease, advanced age or other QT-prolonging drugs.
What this interaction means in plain words
Hydroxyzine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation; posaconazole may also modestly raise hydroxyzine exposure via CYP3A4 inhibition.
What to do
Avoid the combination where possible and choose a non-QT-prolonging antihistamine. If unavoidable, use the lowest hydroxyzine dose, correct electrolytes and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Posaconazole?
MediHelp rates the interaction as major. Hydroxyzine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so concurrent use may increase the risk of torsades de pointes. Risk is greater in patients with electrolyte imbalance, heart disease, advanced age or other QT-prolonging drugs.
How serious is the interaction between Hydroxyzine and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-QT-prolonging antihistamine. If unavoidable, use the lowest hydroxyzine dose, correct electrolytes and monitor the ECG.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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