Drug interactions
Hydroxyzine + Propofol
Severity: Moderate
Hydroxyzine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is sedating and can potentiate propofol, increasing the risk of oversedation and delayed recovery. Hydroxyzine also has QT-prolonging potential.
What this interaction means in plain words
Hydroxyzine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and GABA-A potentiation.
What to do
Reduce propofol dose and titrate to effect. Monitor sedation, ventilation and ECG when QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Propofol?
MediHelp rates the interaction as moderate. Hydroxyzine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is sedating and can potentiate propofol, increasing the risk of oversedation and delayed recovery. Hydroxyzine also has QT-prolonging potential.
How serious is the interaction between Hydroxyzine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol dose and titrate to effect. Monitor sedation, ventilation and ECG when QT risk factors are present.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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