Drug interactions
Hyoscyamine + Risperidone
Severity: Moderate
Hyoscyamine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a potent antimuscarinic that may add to the anticholinergic effects of risperidone. Together they may cause constipation, urinary retention, tachycardia, blurred vision and confusion, with higher risk in elderly patients.
What this interaction means in plain words
Hyoscyamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Risperidone belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity, especially in older adults or those with dementia. Use the lowest effective hyoscyamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Risperidone?
MediHelp rates the interaction as moderate. Hyoscyamine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a potent antimuscarinic that may add to the anticholinergic effects of risperidone. Together they may cause constipation, urinary retention, tachycardia, blurred vision and confusion, with higher risk in elderly patients.
How serious is the interaction between Hyoscyamine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults or those with dementia. Use the lowest effective hyoscyamine dose.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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