Drug interactions
Hyoscyamine + Tiotropium-olodaterol
Severity: Moderate
Hyoscyamine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine adds systemic antimuscarinic effects to tiotropium, increasing dry mouth, constipation, urinary retention, tachycardia and blurred vision. Older adults and those with glaucoma or prostatic hypertrophy are at higher risk.
What this interaction means in plain words
Hyoscyamine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic adverse effects and use the lowest effective hyperscyamine dose. Avoid in narrow-angle glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Hyoscyamine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine adds systemic antimuscarinic effects to tiotropium, increasing dry mouth, constipation, urinary retention, tachycardia and blurred vision. Older adults and those with glaucoma or prostatic hypertrophy are at higher risk.
How serious is the interaction between Hyoscyamine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and use the lowest effective hyperscyamine dose. Avoid in narrow-angle glaucoma or urinary retention.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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