Drug interactions
Hyoscyamine + Trazodone
Severity: Minor
Hyoscyamine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a potent antimuscarinic, and trazodone adds a small anticholinergic burden along with sedation. The combination may increase dry mouth, constipation, urinary retention, drowsiness and confusion, particularly in older adults.
What this interaction means in plain words
Hyoscyamine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyoscyamine belongs to Genitourinary; Trazodone belongs to Central Nervous System.
Why it happens
Additive antimuscarinic and sedative effects.
What to do
Monitor for anticholinergic effects and excessive sedation, especially in elderly patients. Lower the hyoscyamine dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Trazodone?
MediHelp rates the interaction as minor. Hyoscyamine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hyoscyamine is a potent antimuscarinic, and trazodone adds a small anticholinergic burden along with sedation. The combination may increase dry mouth, constipation, urinary retention, drowsiness and confusion, particularly in older adults.
How serious is the interaction between Hyoscyamine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and excessive sedation, especially in elderly patients. Lower the hyoscyamine dose if symptoms occur.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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