Drug interactions
Hyoscyamine + Trimipramine
Severity: Moderate
Hyoscyamine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic activity, so combined use can produce additive anticholinergic effects including dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are at higher risk of delirium and ileus.
What this interaction means in plain words
Hyoscyamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic (pharmacodynamic) effects.
What to do
Monitor for anticholinergic toxicity and lower the dose of one or both agents if symptoms develop. Avoid in patients with narrow-angle glaucoma, urinary retention or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Trimipramine?
MediHelp rates the interaction as moderate. Hyoscyamine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can produce additive anticholinergic effects including dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are at higher risk of delirium and ileus.
How serious is the interaction between Hyoscyamine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and lower the dose of one or both agents if symptoms develop. Avoid in patients with narrow-angle glaucoma, urinary retention or ileus.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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