Drug interactions
Idelalisib + Ixazomib
Severity: Minor
Idelalisib and Ixazomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib strongly inhibits CYP3A4, but strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. Both drugs can cause cytopenias and diarrhea, so overlapping toxicity deserves attention.
What this interaction means in plain words
Idelalisib and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Ixazomib belongs to Oncology.
Why it happens
Idelalisib inhibits CYP3A4, which contributes little to ixazomib clearance.
What to do
No pharmacokinetic dose adjustment is needed; monitor blood counts and gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Ixazomib?
MediHelp rates the interaction as minor. Idelalisib and Ixazomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib strongly inhibits CYP3A4, but strong CYP3A inhibitors did not meaningfully change ixazomib exposure in clinical studies. Both drugs can cause cytopenias and diarrhea, so overlapping toxicity deserves attention.
How serious is the interaction between Idelalisib and Ixazomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No pharmacokinetic dose adjustment is needed; monitor blood counts and gastrointestinal toxicity.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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