Drug interactions
Idelalisib + Lacosamide
Severity: Minor
Idelalisib and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor, but lacosamide has multiple metabolic pathways and low CYP3A dependence. Clinically important increases are unlikely, although some rise in exposure is possible.
What this interaction means in plain words
Idelalisib and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Lacosamide belongs to Central Nervous System.
Why it happens
Idelalisib inhibits CYP3A4, a minor contributor to lacosamide clearance.
What to do
No dose adjustment is usually required. Monitor for dizziness and ECG PR interval changes if there are cardiac risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Lacosamide?
MediHelp rates the interaction as minor. Idelalisib and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A inhibitor, but lacosamide has multiple metabolic pathways and low CYP3A dependence. Clinically important increases are unlikely, although some rise in exposure is possible.
How serious is the interaction between Idelalisib and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for dizziness and ECG PR interval changes if there are cardiac risk factors.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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