Drug interactions
Idelalisib + Linagliptin
Severity: Minor
Idelalisib and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A and P-gp inhibitor and may increase linagliptin concentrations. Linagliptin has a wide margin of safety and a large non-metabolic elimination component, so the effect is modest.
What this interaction means in plain words
Idelalisib and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Linagliptin belongs to Endocrine.
Why it happens
CYP3A4 and P-gp inhibition by idelalisib reduces linagliptin elimination.
What to do
No dose adjustment is needed. Monitor for hypoglycemia, especially with other antidiabetic drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Linagliptin?
MediHelp rates the interaction as minor. Idelalisib and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A and P-gp inhibitor and may increase linagliptin concentrations. Linagliptin has a wide margin of safety and a large non-metabolic elimination component, so the effect is modest.
How serious is the interaction between Idelalisib and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for hypoglycemia, especially with other antidiabetic drugs.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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