Drug interactions
Idelalisib + Palbociclib
Severity: Major
Idelalisib and Palbociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can considerably increase palbociclib exposure. This increases the risk of neutropenia and other toxicities.
What this interaction means in plain words
Idelalisib and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Idelalisib inhibits CYP3A, reducing palbociclib clearance.
What to do
Avoid if possible. If unavoidable, reduce palbociclib to 75 mg daily and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Palbociclib
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Palbociclib?
MediHelp rates the interaction as major. Idelalisib and Palbociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can considerably increase palbociclib exposure. This increases the risk of neutropenia and other toxicities.
How serious is the interaction between Idelalisib and Palbociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce palbociclib to 75 mg daily and monitor blood counts closely.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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