Drug interactions
Idelalisib + Ropivacaine
Severity: Minor
Idelalisib and Ropivacaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor, but ropivacaine is cleared mainly by CYP1A2, with CYP3A4 playing a minor role. A modest rise in ropivacaine exposure is possible.
What this interaction means in plain words
Idelalisib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Ropivacaine belongs to Central Nervous System.
Why it happens
Idelalisib inhibits CYP3A4, a secondary pathway of ropivacaine metabolism.
What to do
No dose change is usually needed for single doses; avoid prolonged infusions and monitor for toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Ropivacaine?
MediHelp rates the interaction as minor. Idelalisib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A inhibitor, but ropivacaine is cleared mainly by CYP1A2, with CYP3A4 playing a minor role. A modest rise in ropivacaine exposure is possible.
How serious is the interaction between Idelalisib and Ropivacaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for single doses; avoid prolonged infusions and monitor for toxicity.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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