Drug interactions
Idelalisib + Vortioxetine
Severity: Moderate
Idelalisib and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may increase vortioxetine concentrations. This may heighten nausea, serotonergic effects and other dose-related adverse reactions.
What this interaction means in plain words
Idelalisib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition by idelalisib decreases the secondary CYP3A4-mediated clearance of vortioxetine.
What to do
Monitor for vortioxetine adverse effects such as nausea, agitation and signs of serotonin toxicity. Reduce the vortioxetine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Vortioxetine?
MediHelp rates the interaction as moderate. Idelalisib and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and may increase vortioxetine concentrations. This may heighten nausea, serotonergic effects and other dose-related adverse reactions.
How serious is the interaction between Idelalisib and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vortioxetine adverse effects such as nausea, agitation and signs of serotonin toxicity. Reduce the vortioxetine dose if adverse effects emerge.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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