Drug interactions
Idelalisib + Zonisamide
Severity: Moderate
Idelalisib and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may raise zonisamide concentrations since CYP3A4 contributes to its clearance. Higher levels could cause dose-related adverse effects.
What this interaction means in plain words
Idelalisib and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Zonisamide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by idelalisib reduces zonisamide metabolism.
What to do
Monitor for zonisamide toxicity such as drowsiness, dizziness and metabolic acidosis. Reduce the zonisamide dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Zonisamide?
MediHelp rates the interaction as moderate. Idelalisib and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may raise zonisamide concentrations since CYP3A4 contributes to its clearance. Higher levels could cause dose-related adverse effects.
How serious is the interaction between Idelalisib and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide toxicity such as drowsiness, dizziness and metabolic acidosis. Reduce the zonisamide dose if adverse effects appear.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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