Drug interactions
Iloperidone + Leuprolide
Severity: Major
Iloperidone and Leuprolide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an antipsychotic that prolongs the QT interval, and leuprolide may contribute further. Concurrent use raises the risk of torsades de pointes.
What this interaction means in plain words
Iloperidone and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation from androgen deprivation (leuprolide) and antipsychotic blockade of cardiac potassium channels (iloperidone).
What to do
Check a baseline ECG and electrolytes, and monitor the QTc after combining. Consider an antipsychotic with lower QT liability if the QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Leuprolide?
MediHelp rates the interaction as major. Iloperidone and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone is an antipsychotic that prolongs the QT interval, and leuprolide may contribute further. Concurrent use raises the risk of torsades de pointes.
How serious is the interaction between Iloperidone and Leuprolide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc after combining. Consider an antipsychotic with lower QT liability if the QTc rises.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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