Drug interactions
Iloperidone + Lisdexamfetamine
Severity: Moderate
Iloperidone and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine and the sedating antipsychotic iloperidone have opposing effects on alertness and dopamine signalling. Stimulant effect may be blunted by the antipsychotic, and iloperidone's QT effect and orthostasis can be compounded by sympathomimetic effects on heart rate and blood pressure.
What this interaction means in plain words
Iloperidone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors (D2 antagonism versus amphetamine-induced dopamine release), plus additive cardiovascular effects.
What to do
Monitor blood pressure, heart rate and psychiatric symptoms, and consider ECG monitoring in patients with QT risk factors. Adjust doses according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Iloperidone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine and the sedating antipsychotic iloperidone have opposing effects on alertness and dopamine signalling. Stimulant effect may be blunted by the antipsychotic, and iloperidone's QT effect and orthostasis can be compounded by sympathomimetic effects on heart rate and blood pressure.
How serious is the interaction between Iloperidone and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and psychiatric symptoms, and consider ECG monitoring in patients with QT risk factors. Adjust doses according to clinical response.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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