Drug interactions
Iloperidone + Medroxyprogesterone
Severity: Minor
Iloperidone and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A4 inhibitor and could modestly raise medroxyprogesterone exposure. The clinical consequence is likely small.
What this interaction means in plain words
Iloperidone and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of medroxyprogesterone.
What to do
No dose adjustment is usually required; monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Medroxyprogesterone?
MediHelp rates the interaction as minor. Iloperidone and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak time-dependent CYP3A4 inhibitor and could modestly raise medroxyprogesterone exposure. The clinical consequence is likely small.
How serious is the interaction between Iloperidone and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for progestogenic adverse effects.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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