Drug interactions
Iloperidone + Prochlorperazine
Severity: Major
Iloperidone and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine-blocking antipsychotics that prolong the QT interval, so combining them raises the risk of torsades de pointes. They also increase the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and sedation.
What this interaction means in plain words
Iloperidone and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, dopamine D2 antagonism and CNS depression.
What to do
Avoid combining where possible, and use a non-QT-prolonging antiemetic instead of prochlorperazine. If unavoidable, monitor the ECG and electrolytes and watch for extrapyramidal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Prochlorperazine?
MediHelp rates the interaction as major. Iloperidone and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are dopamine-blocking antipsychotics that prolong the QT interval, so combining them raises the risk of torsades de pointes. They also increase the risk of extrapyramidal symptoms, neuroleptic malignant syndrome and sedation.
How serious is the interaction between Iloperidone and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and use a non-QT-prolonging antiemetic instead of prochlorperazine. If unavoidable, monitor the ECG and electrolytes and watch for extrapyramidal symptoms.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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