Drug interactions
Iloperidone + Progesterone
Severity: Minor
Iloperidone and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A inhibitor and may slightly increase progesterone exposure. Clinical consequences are likely small.
What this interaction means in plain words
Iloperidone and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
Time-dependent CYP3A4 inhibition by iloperidone reduces progesterone clearance.
What to do
No empiric change needed. Monitor for increased progestogenic effects such as sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Progesterone?
MediHelp rates the interaction as minor. Iloperidone and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is a weak CYP3A inhibitor and may slightly increase progesterone exposure. Clinical consequences are likely small.
How serious is the interaction between Iloperidone and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric change needed. Monitor for increased progestogenic effects such as sedation.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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