Drug interactions
Iloperidone + Propofol
Severity: Moderate
Iloperidone and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating atypical antipsychotic that causes orthostatic hypotension and QT prolongation. With propofol, additive sedation and hypotension are likely, with a possible additive QT effect.
What this interaction means in plain words
Iloperidone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from alpha-1 and H1 blockade; both may affect QT interval.
What to do
Titrate propofol to effect and monitor blood pressure, sedation and ECG. Correct potassium and magnesium abnormalities in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Propofol?
MediHelp rates the interaction as moderate. Iloperidone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating atypical antipsychotic that causes orthostatic hypotension and QT prolongation. With propofol, additive sedation and hypotension are likely, with a possible additive QT effect.
How serious is the interaction between Iloperidone and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor blood pressure, sedation and ECG. Correct potassium and magnesium abnormalities in at-risk patients.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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