Drug interactions
Iloperidone + Vilazodone
Severity: Moderate
Iloperidone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic antidepressant with an antipsychotic can rarely cause serotonin syndrome or neuroleptic malignant syndrome. Iloperidone may also weakly inhibit CYP3A4, modestly raising vilazodone exposure, and both drugs may add to QT or sedative effects.
What this interaction means in plain words
Iloperidone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Pharmacodynamic serotonergic and dopamine-blocking interplay plus weak CYP3A4 inhibition.
What to do
Monitor for mental status change, rigidity, hyperthermia and autonomic instability. Obtain an ECG if other QT-prolonging risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Vilazodone?
MediHelp rates the interaction as moderate. Iloperidone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic antidepressant with an antipsychotic can rarely cause serotonin syndrome or neuroleptic malignant syndrome. Iloperidone may also weakly inhibit CYP3A4, modestly raising vilazodone exposure, and both drugs may add to QT or sedative effects.
How serious is the interaction between Iloperidone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, rigidity, hyperthermia and autonomic instability. Obtain an ECG if other QT-prolonging risks exist.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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