Drug interactions
Iloprost + Propofol
Severity: Moderate
Iloprost and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, and iloprost is a potent vasodilator. Together they may cause more pronounced hypotension, especially with intravenous iloprost.
What this interaction means in plain words
Iloprost and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive vasodilatory and hypotensive pharmacodynamic effects.
What to do
Monitor blood pressure closely and treat hypotension with fluids or vasopressors. Reduce the iloprost infusion rate if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Propofol?
MediHelp rates the interaction as moderate. Iloprost and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, and iloprost is a potent vasodilator. Together they may cause more pronounced hypotension, especially with intravenous iloprost.
How serious is the interaction between Iloprost and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and treat hypotension with fluids or vasopressors. Reduce the iloprost infusion rate if hypotension persists.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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