Drug interactions
Indacaterol + Levoketoconazole
Severity: Moderate
Indacaterol and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole can raise systemic indacaterol exposure, increasing the likelihood of tachycardia, tremor and hypokalemia. Levoketoconazole itself prolongs QT, which adds cardiac concern.
What this interaction means in plain words
Indacaterol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces indacaterol clearance, and levoketoconazole adds QT-prolonging effects.
What to do
Monitor heart rate, potassium and ECG during coadministration. No dose adjustment is usually required at the 75 mcg dose, but reassess if beta-agonist adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Indacaterol with Levoketoconazole?
MediHelp rates the interaction as moderate. Indacaterol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole can raise systemic indacaterol exposure, increasing the likelihood of tachycardia, tremor and hypokalemia. Levoketoconazole itself prolongs QT, which adds cardiac concern.
How serious is the interaction between Indacaterol and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and ECG during coadministration. No dose adjustment is usually required at the 75 mcg dose, but reassess if beta-agonist adverse effects appear.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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