Drug interactions
Indacaterol + Metolazone
Severity: Moderate
Indacaterol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is a potent potassium-wasting diuretic and indacaterol can further lower potassium, so hypokalemia and associated arrhythmias are more likely.
What this interaction means in plain words
Indacaterol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Metolazone belongs to Cardiovascular.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2 mediated intracellular shift.
What to do
Monitor serum potassium and magnesium regularly, and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Metolazone
Frequently asked questions
Can I take Indacaterol with Metolazone?
MediHelp rates the interaction as moderate. Indacaterol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone is a potent potassium-wasting diuretic and indacaterol can further lower potassium, so hypokalemia and associated arrhythmias are more likely.
How serious is the interaction between Indacaterol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly, and supplement as needed.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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