Drug interactions
Indacaterol + Ondansetron
Severity: Moderate
Indacaterol and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron prolongs the QT interval in a dose-dependent manner, and indacaterol may add to this through tachycardia and hypokalemia. This raises the risk of torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Indacaterol and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation with beta-agonist-induced hypokalemia.
What to do
Use the lowest effective ondansetron dose, correct potassium and magnesium, and obtain ECG monitoring in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Indacaterol with Ondansetron?
MediHelp rates the interaction as moderate. Indacaterol and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ondansetron prolongs the QT interval in a dose-dependent manner, and indacaterol may add to this through tachycardia and hypokalemia. This raises the risk of torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Indacaterol and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ondansetron dose, correct potassium and magnesium, and obtain ECG monitoring in patients with cardiac risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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