Drug interactions
Indacaterol + Ranolazine
Severity: Moderate
Indacaterol and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine causes dose-related QT prolongation, and indacaterol may add to arrhythmic risk through sympathetic effects and hypokalemia. The clinical effect is usually modest.
What this interaction means in plain words
Indacaterol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Ranolazine belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization with beta-2 agonist-induced hypokalemia.
What to do
Monitor ECG in patients with other QT risk factors. Keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Indacaterol with Ranolazine?
MediHelp rates the interaction as moderate. Indacaterol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine causes dose-related QT prolongation, and indacaterol may add to arrhythmic risk through sympathetic effects and hypokalemia. The clinical effect is usually modest.
How serious is the interaction between Indacaterol and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with other QT risk factors. Keep potassium and magnesium in the normal range.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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