Drug interactions
Indacaterol + Sotalol
Severity: Major
Indacaterol and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a nonselective beta-blocker that opposes indacaterol's bronchodilator effect and may precipitate bronchospasm. Sotalol also prolongs the QT interval, which indacaterol-related hypokalemia can worsen.
What this interaction means in plain words
Indacaterol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Beta-2 receptor antagonism by sotalol, plus additive QT prolongation.
What to do
Avoid in patients with COPD or asthma where possible and choose a cardioselective alternative. If unavoidable, monitor respiratory status, ECG and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Indacaterol with Sotalol?
MediHelp rates the interaction as major. Indacaterol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a nonselective beta-blocker that opposes indacaterol's bronchodilator effect and may precipitate bronchospasm. Sotalol also prolongs the QT interval, which indacaterol-related hypokalemia can worsen.
How serious is the interaction between Indacaterol and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with COPD or asthma where possible and choose a cardioselective alternative. If unavoidable, monitor respiratory status, ECG and potassium.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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