Drug interactions
Indacaterol + Trimipramine
Severity: Major
Indacaterol and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and may themselves prolong the QT interval. The combination may increase the risk of tachycardia and ventricular arrhythmias.
What this interaction means in plain words
Indacaterol and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Tricyclic potentiation of adrenergic cardiovascular effects plus additive QT prolongation.
What to do
Use only when needed, with ECG monitoring and attention to heart rate and blood pressure. Correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Indacaterol with Trimipramine?
MediHelp rates the interaction as major. Indacaterol and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and may themselves prolong the QT interval. The combination may increase the risk of tachycardia and ventricular arrhythmias.
How serious is the interaction between Indacaterol and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when needed, with ECG monitoring and attention to heart rate and blood pressure. Correct potassium and magnesium.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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