Drug interactions
Indacaterol-glycopyrronium + Pentamidine
Severity: Major
Indacaterol-glycopyrronium and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can prolong the QT interval and cause torsades de pointes, and beta-2 agonists can add to cardiac excitability and lower potassium. Combined use may increase arrhythmic risk.
What this interaction means in plain words
Indacaterol-glycopyrronium and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation with possible beta-agonist related hypokalemia.
What to do
Check baseline ECG, potassium and magnesium, and correct abnormalities before use. Monitor QTc during the pentamidine course or choose an alternative if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Pentamidine?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine can prolong the QT interval and cause torsades de pointes, and beta-2 agonists can add to cardiac excitability and lower potassium. Combined use may increase arrhythmic risk.
How serious is the interaction between Indacaterol-glycopyrronium and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium and magnesium, and correct abnormalities before use. Monitor QTc during the pentamidine course or choose an alternative if feasible.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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