Drug interactions
Indacaterol-glycopyrronium + Posaconazole
Severity: Moderate
Indacaterol-glycopyrronium and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can prolong the QT interval, and indacaterol may add to this. Posaconazole also inhibits CYP3A4 and P-gp, which may raise indacaterol exposure and increase beta-agonist adverse effects.
What this interaction means in plain words
Indacaterol-glycopyrronium and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation and CYP3A4/P-gp inhibition increasing indacaterol exposure.
What to do
Check ECG and electrolytes at baseline and during therapy, and monitor for tremor, tachycardia and palpitations. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Posaconazole?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can prolong the QT interval, and indacaterol may add to this. Posaconazole also inhibits CYP3A4 and P-gp, which may raise indacaterol exposure and increase beta-agonist adverse effects.
How serious is the interaction between Indacaterol-glycopyrronium and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during therapy, and monitor for tremor, tachycardia and palpitations. Correct hypokalemia promptly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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