Drug interactions
Indacaterol-glycopyrronium + Prochlorperazine
Severity: Moderate
Indacaterol-glycopyrronium and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has anticholinergic properties and can prolong the QT interval. Combined with inhaled glycopyrronium, anticholinergic effects may be additive, and indacaterol may add to QT effects.
What this interaction means in plain words
Indacaterol-glycopyrronium and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and possible additive QT prolongation.
What to do
Monitor for dry mouth, constipation, urinary retention and confusion. Check ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Prochlorperazine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine has anticholinergic properties and can prolong the QT interval. Combined with inhaled glycopyrronium, anticholinergic effects may be additive, and indacaterol may add to QT effects.
How serious is the interaction between Indacaterol-glycopyrronium and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dry mouth, constipation, urinary retention and confusion. Check ECG in patients with cardiac risk factors.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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