Drug interactions
Infliximab + Ocrelizumab
Severity: Moderate
Infliximab and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes CD20-positive B cells while infliximab blocks TNF-alpha. Using both may increase the likelihood of serious or opportunistic infections.
What this interaction means in plain words
Infliximab and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression through B-cell depletion and TNF inhibition.
What to do
Avoid combining unless clearly needed, and screen for active infection before dosing. Monitor for infection throughout treatment and for months after ocrelizumab, since B-cell depletion persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Infliximab with Ocrelizumab?
MediHelp rates the interaction as moderate. Infliximab and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes CD20-positive B cells while infliximab blocks TNF-alpha. Using both may increase the likelihood of serious or opportunistic infections.
How serious is the interaction between Infliximab and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly needed, and screen for active infection before dosing. Monitor for infection throughout treatment and for months after ocrelizumab, since B-cell depletion persists.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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