Drug interactions
Infliximab + Pretomanid
Severity: Moderate
Infliximab and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and infliximab can rarely cause liver injury. Using them together may increase the chance of liver injury.
What this interaction means in plain words
Infliximab and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxic potential; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes at baseline and regularly during treatment. Interrupt the offending drugs if significant hepatic injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Infliximab with Pretomanid?
MediHelp rates the interaction as moderate. Infliximab and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid-containing regimens are associated with hepatotoxicity, and infliximab can rarely cause liver injury. Using them together may increase the chance of liver injury.
How serious is the interaction between Infliximab and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes at baseline and regularly during treatment. Interrupt the offending drugs if significant hepatic injury develops.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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