Drug interactions
Infliximab + Vedolizumab
Severity: Moderate
Infliximab and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab is gut-selective, but combining it with a TNF blocker may increase infection risk and is not recommended in labeling. Combination use has been explored in refractory inflammatory bowel disease with specialist oversight.
What this interaction means in plain words
Infliximab and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from systemic TNF-alpha blockade and gut-selective alpha4beta7 integrin inhibition.
What to do
Avoid routine combination; if used in refractory disease, monitor for infection closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Infliximab with Vedolizumab?
MediHelp rates the interaction as moderate. Infliximab and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vedolizumab is gut-selective, but combining it with a TNF blocker may increase infection risk and is not recommended in labeling. Combination use has been explored in refractory inflammatory bowel disease with specialist oversight.
How serious is the interaction between Infliximab and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used in refractory disease, monitor for infection closely.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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