Drug interactions
Insulin degludec-insulin aspart + Linagliptin
Severity: Minor
Insulin degludec-insulin aspart and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a DPP-4 inhibitor to insulin improves glycemic control but can increase the risk of hypoglycemia. The risk is modest because the DPP-4 effect is glucose-dependent.
What this interaction means in plain words
Insulin degludec-insulin aspart and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-insulin aspart belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering: linagliptin raises incretin levels, enhancing glucose-dependent insulin secretion and suppressing glucagon.
What to do
Monitor blood glucose and consider a lower insulin dose when starting linagliptin if the patient is prone to hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Linagliptin?
MediHelp rates the interaction as minor. Insulin degludec-insulin aspart and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Adding a DPP-4 inhibitor to insulin improves glycemic control but can increase the risk of hypoglycemia. The risk is modest because the DPP-4 effect is glucose-dependent.
How serious is the interaction between Insulin degludec-insulin aspart and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider a lower insulin dose when starting linagliptin if the patient is prone to hypoglycemia.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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