Drug interactions
Insulin degludec-insulin aspart + Methylprednisolone
Severity: Moderate
Insulin degludec-insulin aspart and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic methylprednisolone causes hyperglycemia and insulin resistance, reducing the effect of insulin. Higher insulin doses are often needed during treatment, especially with high doses, and requirements fall after tapering.
What this interaction means in plain words
Insulin degludec-insulin aspart and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Methylprednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic glucose output and reduce peripheral insulin sensitivity, antagonizing insulin.
What to do
Increase glucose monitoring and titrate insulin during steroid therapy. Reduce insulin as the steroid dose is tapered or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Methylprednisolone?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic methylprednisolone causes hyperglycemia and insulin resistance, reducing the effect of insulin. Higher insulin doses are often needed during treatment, especially with high doses, and requirements fall after tapering.
How serious is the interaction between Insulin degludec-insulin aspart and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring and titrate insulin during steroid therapy. Reduce insulin as the steroid dose is tapered or stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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