Drug interactions
Insulin degludec-insulin aspart + Metolazone
Severity: Moderate
Insulin degludec-insulin aspart and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, a thiazide-like diuretic, can raise blood glucose and reduce insulin effectiveness. Marked hypokalemia, especially when combined with loop diuretics, may worsen this.
What this interaction means in plain words
Insulin degludec-insulin aspart and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and reduced insulin secretion and sensitivity oppose insulin action.
What to do
Monitor blood glucose and serum potassium when starting or adjusting metolazone. Adjust the insulin dose and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Metolazone
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Metolazone?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, a thiazide-like diuretic, can raise blood glucose and reduce insulin effectiveness. Marked hypokalemia, especially when combined with loop diuretics, may worsen this.
How serious is the interaction between Insulin degludec-insulin aspart and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when starting or adjusting metolazone. Adjust the insulin dose and correct hypokalemia.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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