Drug interactions
Insulin degludec-insulin aspart + Miglitol
Severity: Moderate
Insulin degludec-insulin aspart and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol lowers postprandial glucose and adds to the effect of insulin, increasing hypoglycemia risk. Because miglitol delays carbohydrate absorption, treating hypoglycemia with sucrose or starch may be ineffective.
What this interaction means in plain words
Insulin degludec-insulin aspart and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Additive glucose lowering: miglitol inhibits intestinal alpha-glucosidase, delaying carbohydrate absorption.
What to do
Treat hypoglycemia with oral glucose (dextrose) rather than sucrose or complex carbohydrates, and monitor blood glucose. Reduce the insulin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Miglitol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miglitol lowers postprandial glucose and adds to the effect of insulin, increasing hypoglycemia risk. Because miglitol delays carbohydrate absorption, treating hypoglycemia with sucrose or starch may be ineffective.
How serious is the interaction between Insulin degludec-insulin aspart and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Treat hypoglycemia with oral glucose (dextrose) rather than sucrose or complex carbohydrates, and monitor blood glucose. Reduce the insulin dose if needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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