Drug interactions
Insulin degludec-insulin aspart + Pentoxifylline
Severity: Minor
Insulin degludec-insulin aspart and Pentoxifylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline has been reported to enhance the glucose-lowering effect of insulin in some patients. Hypoglycemia is a theoretical or occasional concern.
What this interaction means in plain words
Insulin degludec-insulin aspart and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-insulin aspart belongs to Endocrine; Pentoxifylline belongs to Cardiovascular.
Why it happens
Mechanism is not well established; possible additive effect on glucose lowering.
What to do
Monitor blood glucose when pentoxifylline is started and reduce insulin if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Pentoxifylline?
MediHelp rates the interaction as minor. Insulin degludec-insulin aspart and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentoxifylline has been reported to enhance the glucose-lowering effect of insulin in some patients. Hypoglycemia is a theoretical or occasional concern.
How serious is the interaction between Insulin degludec-insulin aspart and Pentoxifylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pentoxifylline is started and reduce insulin if hypoglycemia occurs.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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