Drug interactions
Insulin degludec-insulin aspart + Sotalol
Severity: Moderate
Insulin degludec-insulin aspart and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol, a nonselective beta-blocker, can mask the adrenergic symptoms of hypoglycemia and delay glucose recovery in insulin-treated patients.
What this interaction means in plain words
Insulin degludec-insulin aspart and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Nonselective beta blockade masks sympathetic symptoms and impairs glycogenolysis.
What to do
Monitor blood glucose more frequently and counsel the patient that sweating may be the main warning sign. Adjust insulin doses based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Sotalol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol, a nonselective beta-blocker, can mask the adrenergic symptoms of hypoglycemia and delay glucose recovery in insulin-treated patients.
How serious is the interaction between Insulin degludec-insulin aspart and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently and counsel the patient that sweating may be the main warning sign. Adjust insulin doses based on readings.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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