Drug interactions
Insulin glargine + Lanreotide
Severity: Moderate
Insulin glargine and Lanreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can shift glucose control in either direction in people using insulin. Both hypoglycemia and hyperglycemia have been reported.
What this interaction means in plain words
Insulin glargine and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Lanreotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism inhibits pancreatic insulin and glucagon release, altering the insulin dose requirement.
What to do
Monitor glucose closely when starting or changing the lanreotide dose, and adjust the insulin glargine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Lanreotide
- Lanreotide + Quinidine Major
- Alogliptin-metformin + Lanreotide Moderate
- Canagliflozin-metformin + Lanreotide Moderate
- Cyclosporin + Lanreotide Moderate
- Dapagliflozin-metformin + Lanreotide Moderate
- Empagliflozin-metformin + Lanreotide Moderate
Frequently asked questions
Can I take Insulin glargine with Lanreotide?
MediHelp rates the interaction as moderate. Insulin glargine and Lanreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanreotide suppresses insulin, glucagon and growth hormone secretion, which can shift glucose control in either direction in people using insulin. Both hypoglycemia and hyperglycemia have been reported.
How serious is the interaction between Insulin glargine and Lanreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting or changing the lanreotide dose, and adjust the insulin glargine dose accordingly.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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