Drug interactions
Ipratropium + Umeclidinium
Severity: Moderate
Ipratropium and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled antimuscarinic bronchodilators, so using them together duplicates therapy and raises the risk of anticholinergic effects such as dry mouth, urinary retention, glaucoma worsening and tachycardia. It offers little added bronchodilator benefit.
What this interaction means in plain words
Ipratropium and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium belongs to Respiratory; Umeclidinium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects at the same receptors.
What to do
Avoid combining the two; stop ipratropium when umeclidinium is started, and if combined, monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Umeclidinium?
MediHelp rates the interaction as moderate. Ipratropium and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled antimuscarinic bronchodilators, so using them together duplicates therapy and raises the risk of anticholinergic effects such as dry mouth, urinary retention, glaucoma worsening and tachycardia. It offers little added bronchodilator benefit.
How serious is the interaction between Ipratropium and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; stop ipratropium when umeclidinium is started, and if combined, monitor for anticholinergic effects.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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