Drug interactions
Isotretinoin + Teriflunomide
Severity: Moderate
Isotretinoin and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isotretinoin is partly metabolized by CYP2C8, which teriflunomide inhibits. Exposure may increase modestly, with possible higher rates of retinoid adverse effects. Both drugs can also affect the liver and are teratogenic.
What this interaction means in plain words
Isotretinoin and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isotretinoin belongs to Dermatology; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 by teriflunomide may reduce isotretinoin clearance.
What to do
Monitor liver enzymes, lipids and retinoid adverse effects; maintain strict contraception requirements for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Isotretinoin
- Demeclocycline + Isotretinoin Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Isotretinoin + Oxytetracycline Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Aminolevulinic acid + Isotretinoin Major
- Doxycycline + Isotretinoin Major
Frequently asked questions
Can I take Isotretinoin with Teriflunomide?
MediHelp rates the interaction as moderate. Isotretinoin and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isotretinoin is partly metabolized by CYP2C8, which teriflunomide inhibits. Exposure may increase modestly, with possible higher rates of retinoid adverse effects. Both drugs can also affect the liver and are teratogenic.
How serious is the interaction between Isotretinoin and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, lipids and retinoid adverse effects; maintain strict contraception requirements for both drugs.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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