Drug interactions
Itraconazole + Ivermectin
Severity: Minor
Itraconazole and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise ivermectin exposure, which could increase the risk of neurotoxicity at high exposure. At standard doses the clinical effect is usually small.
What this interaction means in plain words
Itraconazole and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Ivermectin belongs to Anti Parasitic.
Why it happens
Itraconazole inhibits P-glycoprotein and CYP3A4, reducing ivermectin efflux and clearance.
What to do
No routine dose change is required; monitor for dizziness, ataxia or other CNS adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Frequently asked questions
Can I take Itraconazole with Ivermectin?
MediHelp rates the interaction as minor. Itraconazole and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may raise ivermectin exposure, which could increase the risk of neurotoxicity at high exposure. At standard doses the clinical effect is usually small.
How serious is the interaction between Itraconazole and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for dizziness, ataxia or other CNS adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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