Drug interactions
Itraconazole + Maraviroc
Severity: Major
Itraconazole and Maraviroc: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases maraviroc concentrations, which can cause postural hypotension and other dose-related adverse effects. The effect is more clinically relevant in severe renal impairment.
What this interaction means in plain words
Itraconazole and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Maraviroc belongs to Anti Virals.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, reducing maraviroc clearance and efflux.
What to do
Reduce maraviroc to 150 mg twice daily when given with strong CYP3A4 inhibitors without a CYP3A inducer, and avoid in severe renal impairment (CrCl below 30 mL/min). Monitor blood pressure and for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Itraconazole with Maraviroc?
MediHelp rates the interaction as major. Itraconazole and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases maraviroc concentrations, which can cause postural hypotension and other dose-related adverse effects. The effect is more clinically relevant in severe renal impairment.
How serious is the interaction between Itraconazole and Maraviroc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce maraviroc to 150 mg twice daily when given with strong CYP3A4 inhibitors without a CYP3A inducer, and avoid in severe renal impairment (CrCl below 30 mL/min). Monitor blood pressure and for adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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