Drug interactions
Itraconazole + Montelukast
Severity: Minor
Itraconazole and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4, a secondary route for montelukast, and may modestly raise levels. The clinical effect is generally minimal because CYP2C8 is the main pathway.
What this interaction means in plain words
Itraconazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Montelukast belongs to Respiratory.
Why it happens
CYP3A4 inhibition by itraconazole reduces part of montelukast metabolism.
What to do
No dose adjustment is needed. Monitor for montelukast adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Montelukast?
MediHelp rates the interaction as minor. Itraconazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole strongly inhibits CYP3A4, a secondary route for montelukast, and may modestly raise levels. The clinical effect is generally minimal because CYP2C8 is the main pathway.
How serious is the interaction between Itraconazole and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for montelukast adverse effects during prolonged co-therapy.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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